abstract：BACKGROUND:In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38) demonstrated that treatment with prasugrel versus clopid...

journal_title：Circulation

authors： Mahoney EM,Wang K,Arnold SV,Proskorovsky I,Wiviott S,Antman E,Braunwald E,Cohen DJ

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Dispatcher-assisted cardiopulmonary resuscitation (CPR) instructions can increase bystander CPR and thereby increase the rate of survival from cardiac arrest. The risk of bystander CPR for patients not in arrest is uncertain and has implications for how assertive dispatch is in instructing CPR. We determined...

journal_title：Circulation

authors： White L,Rogers J,Bloomingdale M,Fahrenbruch C,Culley L,Subido C,Eisenberg M,Rea T

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:In patients with acute myocardial infarction (AMI), hyperglycemia predicts death, but the prognostic significance of hypoglycemia is controversial. METHODS AND RESULTS:We evaluated the prognostic significance of hypoglycemia and hyperglycemia in 30 536 AMI patients in a post hoc analysis of 2 large trials o...

journal_title：Circulation

authors： Goyal A,Mehta SR,Díaz R,Gerstein HC,Afzal R,Xavier D,Liu L,Pais P,Yusuf S

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Angina symptoms have been reported to predict mortality in men. The aim of this study was to investigate the association between angina symptoms and mortality in women. METHODS AND RESULTS:In 2004, 873 older participants in the Australian Longitudinal Study on Women's Health with self-reported ischemic hear...

journal_title：Circulation

authors： Berecki-Gisolf J,Humphreyes-Reid L,Wilson A,Dobson A

更新日期：2009-12-08 00:00:00

abstract：BACKGROUND:The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (> or =75 years of age). METHODS AND RESULTS:We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8+/-1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) ...

journal_title：Circulation

authors： Hachamovitch R,Kang X,Amanullah AM,Abidov A,Hayes SW,Friedman JD,Cohen I,Thomson LE,Germano G,Berman DS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The aim of this prospective, randomized study was to examine whether additional school exercise lessons would result in improved peak oxygen uptake (primary end point) and body mass index-standard deviation score, motor and coordinative abilities, circulating progenitor cells, and high-density lipoprotein ch...

journal_title：Circulation

authors： Walther C,Gaede L,Adams V,Gelbrich G,Leichtle A,Erbs S,Sonnabend M,Fikenzer K,Körner A,Kiess W,Bruegel M,Thiery J,Schuler G

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Although there is a statistically significant association between modestly raised baseline plasma C-reactive protein (CRP) values and future cardiovascular events, the debate is still unsettled in regard to whether CRP plays a causal role in the pathogenesis of atherosclerosis. METHODS AND RESULTS:We genera...

journal_title：Circulation

authors： Koike T,Kitajima S,Yu Y,Nishijima K,Zhang J,Ozaki Y,Morimoto M,Watanabe T,Bhakdi S,Asada Y,Chen YE,Fan J

更新日期：2009-11-24 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that several subsets of regulatory T cells that actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer of novel regulatory T cells expressing latency-associated peptide ...

journal_title：Circulation

authors： Sasaki N,Yamashita T,Takeda M,Shinohara M,Nakajima K,Tawa H,Usui T,Hirata K

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:Genetic testing for long-QT syndrome (LQTS) has diagnostic, prognostic, and therapeutic implications. Hundreds of causative mutations in 12 known LQTS-susceptibility genes have been identified. Genetic testing that includes the 3 most commonly mutated genes is available clinically. Distinguishing pathogenic ...

journal_title：Circulation

authors： Kapa S,Tester DJ,Salisbury BA,Harris-Kerr C,Pungliya MS,Alders M,Wilde AA,Ackerman MJ

更新日期：2009-11-03 00:00:00

abstract：BACKGROUND:Vasoplegic syndrome is a form of vasodilatory shock that can occur after cardiopulmonary bypass (CPB). We hypothesized that the severity and duration of the decline in mean arterial pressure immediately after CPB is begun can be used as a predictor of patients will develop vasoplegia in the immediate post-CP...

journal_title：Circulation

authors： Levin MA,Lin HM,Castillo JG,Adams DH,Reich DL,Fischer GW

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:Patients with peripheral arterial disease are at high risk of ischemic events and therefore are treated with antithrombotics. In patients with coronary artery disease or cerebrovascular disease, bleeding is related to the subsequent occurrence of ischemic events. Our objective was to assess whether this is a...

journal_title：Circulation

authors： van Hattum ES,Algra A,Lawson JA,Eikelboom BC,Moll FL,Tangelder MJ

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:Currently, only anecdotal information exists on the presentation and outcome of coronary arterial injury after ablation procedures. METHODS AND RESULTS:Four patients who sustained coronary artery injury of a cohort of patients undergoing 4655 consecutive ablation procedures (0.09%) are described. The patien...

journal_title：Circulation

authors： Roberts-Thomson KC,Steven D,Seiler J,Inada K,Koplan BA,Tedrow UB,Epstein LM,Stevenson WG

更新日期：2009-10-13 00:00:00

abstract：BACKGROUND:Inflammation and thrombosis coexist in several disorders. Although it is recognized that leukocytes may induce a procoagulant state at sites of inflammation, the critical molecular determinants of this process remain largely unknown. METHODS AND RESULTS:To examine mechanisms of inflammation-induced thrombos...

journal_title：Circulation

authors： Hirahashi J,Hishikawa K,Kaname S,Tsuboi N,Wang Y,Simon DI,Stavrakis G,Shimosawa T,Xiao L,Nagahama Y,Suzuki K,Fujita T,Mayadas TN

更新日期：2009-09-29 00:00:00

abstract：BACKGROUND:Soluble stem cell factor (SCF) has been shown to mobilize bone marrow stem cells and improve cardiac repair after myocardial infarction (MI). However, the effect of membrane-associated SCF on cardiac remodeling after MI is not known. The present study investigated the effects of cardiomyocyte-specific overex...

journal_title：Circulation

authors： Xiang FL,Lu X,Hammoud L,Zhu P,Chidiac P,Robbins J,Feng Q

更新日期：2009-09-22 00:00:00

abstract：BACKGROUND:Autograft reinforcement interventions (R) during the Ross procedure are intended to preserve autograft function and improve durability. The aim of this study is to evaluate this hypothesis. METHODS AND RESULTS:1335 adult patients (mean age:43.5+/-12.0 years) underwent a Ross procedure (subcoronary, SC, n=63...

journal_title：Circulation

authors： Charitos EI,Hanke T,Stierle U,Robinson DR,Bogers AJ,Hemmer W,Bechtel M,Misfeld M,Gorski A,Boehm JO,Rein JG,Botha CA,Lange R,Hoerer J,Moritz A,Wahlers T,Franke UF,Breuer M,Ferrari-Kuehne K,Hetzer R,Huebler M,Ziem

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the impact of concurrent cardiac procedures (CCP) on patient outcomes after HeartMate II (HMII) left ventricular assist device implantation. METHODS AND RESULTS:Two hundred eighty-one patients underwent implantation of a HMII as a bridge to transplantation from M...

journal_title：Circulation

authors： Pal JD,Klodell CT,John R,Pagani FD,Rogers JG,Farrar DJ,Milano CA,HeartMate II Clinical Investigators.

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:The site of cannulation for repair of ascending aortic dissection remains controversial. We present our experience with ascending aortic cannulation for acute aortic dissection type A. METHODS AND RESULTS:From January 1988 to September 2007, we operated on 242 patients for acute aortic dissection type A. Me...

journal_title：Circulation

authors： Kamiya H,Kallenbach K,Halmer D,Ozsöz M,Ilg K,Lichtenberg A,Karck M

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:Minimally invasive coronary artery bypass grafting (MICS CABG) is a novel coronary operation that does not require infrastructure and is potentially available to all cardiac surgeons. It aims at decreasing the invasiveness of conventional CABG while preserving the applicability and durability of surgical rev...

journal_title：Circulation

authors： McGinn JT Jr,Usman S,Lapierre H,Pothula VR,Mesana TG,Ruel M

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:The risk of syncope occurring while driving has obvious implications for personal and public safety. We aimed to define the clinical characteristics, causes, and prognosis of syncope while driving. METHODS AND RESULTS:In this case-control study of consecutive patients evaluated for syncope from 1996 through...

journal_title：Circulation

authors： Sorajja D,Nesbitt GC,Hodge DO,Low PA,Hammill SC,Gersh BJ,Shen WK

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction

journal_title：Circulation

authors： Levy WC,Lee KL,Hellkamp AS,Poole JE,Mozaffarian D,Linker DT,Maggioni AP,Anand I,Poole-Wilson PA,Fishbein DP,Johnson G,Anderson J,Mark DB,Bardy GH

更新日期：2009-09-08 00:00:00

abstract：BACKGROUND:Platelet aggregation plays a critical role in myocardial infarction and stroke; however, the role of platelet secretion in atherosclerotic vascular disease is poorly understood. Therefore, we examined the hypothesis that platelet dense-granule secretion modulates thrombosis, inflammation, and atherosclerotic...

journal_title：Circulation

authors： King SM,McNamee RA,Houng AK,Patel R,Brands M,Reed GL

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The cyclin-dependent kinase inhibitor p27(kip1) is a key regulator of smooth muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We therefore hypothesized that common genetic variations or single nucleotide polymorphisms in p27(kip1) may serve as a useful tool in risk ...

journal_title：Circulation

authors： van Tiel CM,Bonta PI,Rittersma SZ,Beijk MA,Bradley EJ,Klous AM,Koch KT,Baas F,Jukema JW,Pons D,Sampietro ML,Pannekoek H,de Winter RJ,de Vries CJ

更新日期：2009-08-25 00:00:00

abstract：:Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offset its benefits. Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been de...

journal_title：Circulation

authors： Patel C,Yan GX,Kowey PR

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:Patients with prior atherosclerosis in 1 or more vascular territories (coronary, cerebrovascular, or peripheral arterial) who present with acute coronary syndromes have high cardiovascular risk and may benefit significantly from evidence-based therapies, yet whether these are used consistently is unknown. M...

journal_title：Circulation

authors： Brilakis ES,Hernandez AF,Dai D,Peterson ED,Banerjee S,Fonarow GC,Cannon CP,Bhatt DL

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 gene and dysregulation of transforming growth factor-beta (TGF-beta). Recent evidence suggests that losartan, an angiotensin II type 1 blocker that blunts TGF-beta activation, may be an effective treatment for MFS. We hypothesized that dysregula...

journal_title：Circulation

authors： Matt P,Schoenhoff F,Habashi J,Holm T,Van Erp C,Loch D,Carlson OD,Griswold BF,Fu Q,De Backer J,Loeys B,Huso DL,McDonnell NB,Van Eyk JE,Dietz HC,GenTAC Consortium.

更新日期：2009-08-11 00:00:00

abstract：BACKGROUND:Nuclear reprogramming provides an emerging strategy to produce embryo-independent pluripotent stem cells from somatic tissue. Induced pluripotent stem cells (iPS) demonstrate aptitude for de novo cardiac differentiation, yet their potential for heart disease therapy has not been tested. METHODS AND RESULTS:...

journal_title：Circulation

authors： Nelson TJ,Martinez-Fernandez A,Yamada S,Perez-Terzic C,Ikeda Y,Terzic A

更新日期：2009-08-04 00:00:00

abstract：BACKGROUND:Cardiac arrest without evident cardiac disease may be caused by subclinical genetic conditions. Provocative testing to unmask a phenotype is often necessary to detect primary electrical disease, direct genetic testing, and perform family screening. METHODS AND RESULTS:Patients with apparently unexplained ca...

journal_title：Circulation

authors： Krahn AD,Healey JS,Chauhan V,Birnie DH,Simpson CS,Champagne J,Gardner M,Sanatani S,Exner DV,Klein GJ,Yee R,Skanes AC,Gula LJ,Gollob MH

更新日期：2009-07-28 00:00:00

abstract：BACKGROUND:Although angina is often caused by atherosclerotic obstruction of the coronary arteries, patients with similar amounts of myocardial ischemia may vary widely in their symptoms. We sought to compare clinical and psychosocial characteristics associated with more frequent angina after adjusting for the amount o...

journal_title：Circulation

authors： Arnold SV,Spertus JA,Ciechanowski PS,Soine LA,Jordan-Keith K,Caldwell JH,Sullivan MD

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:The hypoxia-inducible transcription factor (HIF) subunits are destabilized via the O(2)-dependent prolyl hydroxylase domain proteins (PHD1, PHD2, and PHD3). We investigated whether inhibition of PHDs via upregulating HIF might promote postischemic neovascularization. METHODS AND RESULTS:Mice with right femo...

journal_title：Circulation

authors： Loinard C,Ginouvès A,Vilar J,Cochain C,Zouggari Y,Recalde A,Duriez M,Lévy BI,Pouysségur J,Berra E,Silvestre JS

更新日期：2009-07-07 00:00:00

abstract：BACKGROUND:CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogen...

journal_title：Circulation

authors： Jansson AM,Aukrust P,Ueland T,Smith C,Omland T,Hartford M,Caidahl K

更新日期：2009-06-30 00:00:00

abstract：BACKGROUND:Several mortality risk scores exist in cardiac surgery. All include a considerable number of independent risk factors. In elective cardiac surgery patients, the operative mortality is low, the number of events recorded per year is limited, and the risk model may be overfitted. The present study aims to devel...

journal_title：Circulation

authors： Ranucci M,Castelvecchio S,Menicanti L,Frigiola A,Pelissero G

更新日期：2009-06-23 00:00:00

abstract：BACKGROUND:Adults with obesity or type 2 diabetes mellitus (T2DM) are at higher risk for stroke and myocardial infarction. Increased carotid intima-media thickness (cIMT) and stiffness are associated with these adverse outcomes. We compared carotid arteries in youth who were lean, were obese, or had T2DM. METHODS AND ...

journal_title：Circulation

authors： Urbina EM,Kimball TR,McCoy CE,Khoury PR,Daniels SR,Dolan LM

更新日期：2009-06-09 00:00:00

abstract：BACKGROUND:Myocardial afterload depends on left ventricular (LV) cavity size, pressure, and wall thickness, all of which change markedly throughout ejection. We assessed the relationship between instantaneous ejection-phase pressure and myocardial stress and the effect of arterial wave reflections on myocardial stress ...

journal_title：Circulation

authors： Chirinos JA,Segers P,Gupta AK,Swillens A,Rietzschel ER,De Buyzere ML,Kirkpatrick JN,Gillebert TC,Wang Y,Keane MG,Townsend R,Ferrari VA,Wiegers SE,St John Sutton M

更新日期：2009-06-02 00:00:00

abstract：BACKGROUND:Nitric oxide (NO)-mediated local regulation of vascular tone is considered to involve endothelial NO synthase (eNOS). However, we recently reported that human forearm basal microvascular tone in vivo is tonically regulated by neuronal NO synthase (nNOS), in contrast to an acetylcholine-stimulated reduction i...

journal_title：Circulation

authors： Seddon M,Melikian N,Dworakowski R,Shabeeh H,Jiang B,Byrne J,Casadei B,Chowienczyk P,Shah AM

更新日期：2009-05-26 00:00:00

abstract：:Cardiovascular specialists have entered an era of renewed interest and enthusiasm surrounding the diagnosis and treatment of valvular heart disease, driven in part by emerging percutaneous therapies for the treatment of aortic, pulmonic, and mitral valve disease. Despite this wave of investigation, little or no attent...

journal_title：Circulation

authors： Rogers JH,Bolling SF

更新日期：2009-05-26 00:00:00

abstract：BACKGROUND:Peak early-diastolic mitral annulus velocity (e') by tissue Doppler imaging has been introduced as a clinical marker of diastolic function. This study investigates whether lengthening load (early-diastolic load) and restoring forces are determinants of e' in addition to rate of left ventricular (LV) relaxati...

journal_title：Circulation

authors： Opdahl A,Remme EW,Helle-Valle T,Lyseggen E,Vartdal T,Pettersen E,Edvardsen T,Smiseth OA

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:Long-term survival after acute kidney injury (AKI) is poorly studied. We report the relationship between long-term mortality and AKI with small changes in serum creatinine during hospitalization after various cardiothoracic surgery procedures. METHODS AND RESULTS:This was a retrospective study of 2973 patie...

journal_title：Circulation

authors： Hobson CE,Yavas S,Segal MS,Schold JD,Tribble CG,Layon AJ,Bihorac A

更新日期：2009-05-12 00:00:00

abstract：BACKGROUND:Recent studies have identified critical roles for microRNAs (miRNAs) in a variety of cellular processes, including regulation of cardiomyocyte death. However, the signature of miRNA expression and possible roles of miRNA in the ischemic heart have been less well studied. METHODS AND RESULTS:We performed miR...

journal_title：Circulation

authors： Ren XP,Wu J,Wang X,Sartor MA,Jones K,Qian J,Nicolaou P,Pritchard TJ,Fan GC

更新日期：2009-05-05 00:00:00

abstract：BACKGROUND:Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content i...

journal_title：Circulation

authors： Lindeman JH,Abdul-Hussien H,van Bockel JH,Wolterbeek R,Kleemann R

更新日期：2009-04-28 00:00:00

abstract：BACKGROUND:Bias in studies of preventive medications can occur when healthier patients are more likely to initiate and adhere to therapy than less healthy patients. We sought evidence of this bias by examining associations between statin exposure and various outcomes that should not be causally affected by statin expos...

journal_title：Circulation

authors： Dormuth CR,Patrick AR,Shrank WH,Wright JM,Glynn RJ,Sutherland J,Brookhart MA

更新日期：2009-04-21 00:00:00